Ontology highlight
ABSTRACT:
SUBMITTER: Wu M
PROVIDER: S-EPMC4185344 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Wu Meng M Peng Siwu S Yang Jialiang J Tu Zhidong Z Cai Xiaoqiang X Cai Chen-Leng CL Wang Zhong Z Zhao Yong Y
Cell research 20140822 10
The sinoatrial node (SAN) is essential for rhythmic beating of the heart; however, our understanding of what controls proper functioning of the SAN remains primitive. To explore molecular control of SAN function, we specifically deleted Baf250a, a key regulatory component of the ATP-dependent chromatin remodeling complex SWI/SNF, in the SAN. Deletion of Baf250a in the SAN led to sinus bradycardia. Time series analysis of dysregulated genes after deletion of Baf250a reveals a transcriptional hier ...[more]