Dataset Information
Simple sulfinate synthesis enables C-H trifluoromethylcyclopropanation.
Ontology highlight
ABSTRACT:
SUBMITTER: Gianatassio R
PROVIDER: S-EPMC4186797 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Simple sulfinate synthesis enables C-H trifluoromethylcyclopropanation.
Angewandte Chemie (International ed. in English) 20140803 37
A simple method to convert readily available carboxylic acids into sulfinate salts by employing an interrupted Barton decarboxylation reaction is reported. A medicinally oriented panel of ten new sulfinate reagents was created using this method, including a key trifluoromethylcyclopropanation reagent, TFCS-Na. The reactivity of six of these salts towards C-H functionalization was field-tested using several different classes of heterocycles. ...[more]