Ontology highlight
ABSTRACT:
SUBMITTER: Lu M
PROVIDER: S-EPMC4186839 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Lu Mo M Jiang Yong-Liang YL Wang Shu S Jin Hua H Zhang Rong-Guang RG Virolle Marie-Joelle MJ Chen Yuxing Y Zhou Cong-Zhao CZ
PloS one 20141006 10
The open reading frame SCO4226 of Streptomyces coelicolor A3(2) encodes an 82-residue hypothetical protein. Biochemical assays revealed that each SCO4226 dimer binds four nickel ions. To decipher the molecular function, we solved the crystal structures of SCO4226 in both apo- and nickel-bound (Ni-SCO4226) forms at 1.30 and 2.04 Å resolution, respectively. Each subunit of SCO4226 dimer adopts a canonical ferredoxin-like fold with five β-strands flanked by two α-helices. In the structure of Ni-SCO ...[more]