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Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis.

ABSTRACT: There are no data about the comparative accuracy of commercially available nucleic acid amplification tests (GeneXpert MTB/RIF and Roche Amplicor) for the diagnosis of tuberculous meningitis (TBM). A total of 148 patients with suspected TBM were evaluated, and cultures served as the reference standard. The sensitivities and specificities (95% confidence interval [CI]) for the Amplicor and Xpert MTB/RIF tests were similar: 46 (31-60) versus 50 (33-67) and 99 (93-100) and 94 (84-99), respectively.

SUBMITTER: Patel VB 

PROVIDER: S-EPMC4187777 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis.

Patel Vinod B VB   Connolly Cathy C   Singh Ravesh R   Lenders Laura L   Matinyenya Brian B   Theron Grant G   Ndung'u Thumbi T   Dheda Keertan K  

Journal of clinical microbiology 20140723 10

There are no data about the comparative accuracy of commercially available nucleic acid amplification tests (GeneXpert MTB/RIF and Roche Amplicor) for the diagnosis of tuberculous meningitis (TBM). A total of 148 patients with suspected TBM were evaluated, and cultures served as the reference standard. The sensitivities and specificities (95% confidence interval [CI]) for the Amplicor and Xpert MTB/RIF tests were similar: 46 (31-60) versus 50 (33-67) and 99 (93-100) and 94 (84-99), respectively. ...[more]

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