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Efficacy of PTX3 and posaconazole combination in a rat model of invasive pulmonary aspergillosis.

ABSTRACT: Posaconazole is currently used for the prophylaxis of invasive pulmonary aspergillosis (IPA). Limitations to posaconazole usage are drug-drug interactions and side effects. PTX3 is an innate immunity glycoprotein with opsonic activity, proven to be protective in IPA animal models. This study investigated the combination of posaconazole with PTX3. The results indicate synergy between PTX3 and posaconazole against aspergillosis, suggesting that a combination of reduced doses of posaconazole with the immune response enhancer PTX3 might represent a treatment option with a higher therapeutic index than posaconazole.

SUBMITTER: Marra E 

PROVIDER: S-EPMC4187902 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Efficacy of PTX3 and posaconazole combination in a rat model of invasive pulmonary aspergillosis.

Marra Emanuele E   Sousa Vitor L VL   Gaziano Roberta R   Pacello M Lucrezia ML   Arseni Brunilde B   Aurisicchio Luigi L   De Santis Rita R   Salvatori Giovanni G  

Antimicrobial agents and chemotherapy 20140728 10

Posaconazole is currently used for the prophylaxis of invasive pulmonary aspergillosis (IPA). Limitations to posaconazole usage are drug-drug interactions and side effects. PTX3 is an innate immunity glycoprotein with opsonic activity, proven to be protective in IPA animal models. This study investigated the combination of posaconazole with PTX3. The results indicate synergy between PTX3 and posaconazole against aspergillosis, suggesting that a combination of reduced doses of posaconazole with t  ...[more]

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