Ontology highlight
ABSTRACT:
SUBMITTER: Hemsley CM
PROVIDER: S-EPMC4187911 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Hemsley Claudia M CM Luo Jamie X JX Andreae Clio A CA Butler Clive S CS Soyer Orkun S OS Titball Richard W RW
Antimicrobial agents and chemotherapy 20140721 10
Noninherited antibiotic resistance is a phenomenon whereby a subpopulation of genetically identical bacteria displays phenotypic tolerance to antibiotics. We show here that compared to Escherichia coli, the clinically relevant genus Burkholderia displays much higher levels of cells that tolerate ceftazidime. By measuring the dynamics of the formation of drug-tolerant cells under conditions that mimic in vivo infections, we show that in Burkholderia bacteria, oxygen levels affect the formation of ...[more]