Unknown

Dataset Information

0

Low testosterone is associated with disability in men with multiple sclerosis.


ABSTRACT: Gonadal steroids may modulate disease course in multiple sclerosis (MS).To assess the prevalence and clinical associations of hypogonadism in men with MS.Male patients, aged 18-65 years, with relapsing-remitting MS (RRMS) or clinically-isolated syndrome (CIS) and their first symptom < 10 years prior were selected from a longitudinal clinical study. We measured their hormones in stored morning blood samples, and collected their Expanded Disability Status Scale (EDSS) scores every 6 months and their Symbol Digit Modalities Test (SDMT) results annually.Our analysis included 96 men with a mean age of 40 years, EDSS of 1.1 and disease duration of 4.6 years. Of these men, 39% were hypogonadal (total testosterone < 288 ng/dL); none showed compensatory elevations in luteinizing hormone. Their low testosterone levels and testosterone:estradiol ratios were negatively correlated with body mass index (BMI) and leptin, and showed no correlation with 25-hydroxy-vitamin D levels. In our primary cross-sectional analyses, there was a negative age-adjusted correlation between total testosterone and EDSS (p = 0.044). In the age-adjusted longitudinal analyses, higher baseline testosterone levels were associated with less decline in SDMT (p = 0.012).Men with MS may experience hypogonadotropic hypogonadism. Low testosterone levels may be associated with worse clinical outcomes. A potential neuroprotective role for testosterone warrants further investigation.

SUBMITTER: Bove R 

PROVIDER: S-EPMC4188801 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Low testosterone is associated with disability in men with multiple sclerosis.

Bove R R   Musallam A A   Healy B C BC   Raghavan K K   Glanz B I BI   Bakshi R R   Weiner H H   De Jager P L PL   Miller K K KK   Chitnis T T  

Multiple sclerosis (Houndmills, Basingstoke, England) 20140407 12


<h4>Background</h4>Gonadal steroids may modulate disease course in multiple sclerosis (MS).<h4>Objective</h4>To assess the prevalence and clinical associations of hypogonadism in men with MS.<h4>Methods</h4>Male patients, aged 18-65 years, with relapsing-remitting MS (RRMS) or clinically-isolated syndrome (CIS) and their first symptom < 10 years prior were selected from a longitudinal clinical study. We measured their hormones in stored morning blood samples, and collected their Expanded Disabil  ...[more]

Similar Datasets

| S-EPMC3952353 | biostudies-literature
| S-EPMC6242870 | biostudies-other
| S-EPMC5433758 | biostudies-literature
| S-EPMC7135931 | biostudies-literature
| S-EPMC7272262 | biostudies-literature
| S-EPMC4971331 | biostudies-literature
| S-EPMC6219694 | biostudies-literature
| S-EPMC5465430 | biostudies-literature
| S-EPMC3887342 | biostudies-other
| S-EPMC6276701 | biostudies-literature