Dataset Information
Nanoparticle tension probes patterned at the nanoscale: impact of integrin clustering on force transmission.
Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC4189618 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Nanoparticle tension probes patterned at the nanoscale: impact of integrin clustering on force transmission.
Nano letters 20140930 10
Herein we aimed to understand how nanoscale clustering of RGD ligands alters the mechano-regulation of their integrin receptors. We combined molecular tension fluorescence microscopy with block copolymer micelle nanolithography to fabricate substrates with arrays of precisely spaced probes that can generate a 10-fold fluorescence response to pN-forces. We found that the mechanism of sensing ligand spacing is force-mediated. This strategy is broadly applicable to investigating receptor clustering ...[more]