Multifunctional RNA nanoparticles.
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ABSTRACT:
SUBMITTER: Afonin KA
PROVIDER: S-EPMC4189619 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Multifunctional RNA nanoparticles.
Afonin Kirill A KA Viard Mathias M Koyfman Alexey Y AY Martins Angelica N AN Kasprzak Wojciech K WK Panigaj Martin M Desai Ravi R Santhanam Arti A Grabow Wade W WW Jaeger Luc L Heldman Eliahu E Reiser Jakob J Chiu Wah W Freed Eric O EO Shapiro Bruce A BA
Nano letters 20140930 10
Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to co ...[more]
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