Ontology highlight
ABSTRACT:
SUBMITTER: Baconguis I
PROVIDER: S-EPMC4190031 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Baconguis Isabelle I Bohlen Christopher J CJ Goehring April A Julius David D Gouaux Eric E
Cell 20140206 4
Acid-sensing ion channels (ASICs) detect extracellular protons produced during inflammation or ischemic injury and belong to the superfamily of degenerin/epithelial sodium channels. Here, we determine the cocrystal structure of chicken ASIC1a with MitTx, a pain-inducing toxin from the Texas coral snake, to define the structure of the open state of ASIC1a. In the MitTx-bound open state and in the previously determined low-pH desensitized state, TM2 is a discontinuous α helix in which the Gly-Ala- ...[more]