Ontology highlight
ABSTRACT:
SUBMITTER: Sun D
PROVIDER: S-EPMC7553779 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
eLife 20200911
Acid-sensing ion channels (ASICs) are proton-gated cation channels that are involved in diverse neuronal processes including pain sensing. The peptide toxin Mambalgin1 (Mamba1) from black mamba snake venom can reversibly inhibit the conductance of ASICs, causing an analgesic effect. However, the detailed mechanism by which Mamba1 inhibits ASIC1s, especially how Mamba1 binding to the extracellular domain affects the conformational changes of the transmembrane domain of ASICs remains elusive. Here ...[more]