Regulation of voltage-dependent calcium channels by RGK proteins.
Ontology highlight
ABSTRACT:
SUBMITTER: Yang T
PROVIDER: S-EPMC4190112 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Regulation of voltage-dependent calcium channels by RGK proteins.
Yang Tingting T Colecraft Henry M HM
Biochimica et biophysica acta 20121010 7
RGK proteins belong to the Ras superfamily of monomeric G-proteins, and currently include four members - Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and are the most potent known intracellular inhibitors of high-voltage-activated Ca²⁺ (Ca(V)1 and Ca(V)2) channels. Here, we review and discuss the evidence in the literature regarding the functional mechanisms, structural determinants, physiological role, and potential practical applications of RGK-mediated inhibition of Ca(V)1 ...[more]
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