Ontology highlight
ABSTRACT:
SUBMITTER: Su SC
PROVIDER: S-EPMC3428598 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Neuron 20120801 4
N-type voltage-gated calcium channels localize to presynaptic nerve terminals and mediate key events including synaptogenesis and neurotransmission. While several kinases have been implicated in the modulation of calcium channels, their impact on presynaptic functions remains unclear. Here we report that the N-type calcium channel is a substrate for cyclin-dependent kinase 5 (Cdk5). The pore-forming α(1) subunit of the N-type calcium channel is phosphorylated in the C-terminal domain, and phosph ...[more]