Ontology highlight
ABSTRACT:
SUBMITTER: Peleg O
PROVIDER: S-EPMC4190652 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Peleg Orit O Choi Jeong-Mo JM Shakhnovich Eugene I EI
Biophysical journal 20141001 7
Hub proteins are proteins that maintain promiscuous molecular recognition. Because they are reported to play essential roles in cellular control, there has been a special interest in the study of their structural and functional properties, yet the mechanisms by which they evolve to maintain functional interactions are poorly understood. By combining biophysical simulations of coarse-grained proteins and analysis of proteins-complex crystallographic structures, we seek to elucidate those mechanis ...[more]