Ontology highlight
ABSTRACT:
SUBMITTER: Li WJ
PROVIDER: S-EPMC4190670 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Li Wen Jun WJ Kou Chang Gui CG Yu Yaqin Y Sun Shilong S Zhang Xuan X Kosten Thomas R TR Zhang Xiang Yang XY
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20120221 4
The gene encoding Catechol-O-methyltransferase (COMT), a dopamine catabolic enzyme, has been associated inconsistently with schizophrenia in spite of consistent evidence for dopaminergic dysfunction in the prefrontal cortex (PFC) of schizophrenia. Since one contribution to this inconsistency might be genetic heterogeneity, this study investigated whether the COMT gene was associated with the development and symptoms of schizophrenia in relatively genetically homogeneous Chinese schizophrenic pat ...[more]