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Association of the catechol-o-methyltransferase gene polymorphisms with Korean autism spectrum disorders.

ABSTRACT: This study evaluated the family-based genetic association between autism spectrum disorders (ASDs) and 5 single-nucleotide polymorphisms (SNPs) in the catechol-o-methyltransferase gene (COMT), which was found among 151 Korean ASDs family trios (dominant model Z = 2.598, P = 0.009, P FDR = 0.045). We found a statistically significant allele transmission or association in terms of the rs6269 SNP in the ASDs trios. Moreover, in the haplotype analysis, the haplotypes with rs6269 demonstrated significant evidence of an association with ASDs (additive model rs6269-rs4818-rs4680-rs769224 haplotype P = 0.004, P FDR = 0.040). Thus, an association may exist between the variants of the COMT gene and the occurrence of ASDs in Koreans.

SUBMITTER: Yoo HJ

PROVIDER: S-EPMC3763120 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Association of the catechol-o-methyltransferase gene polymorphisms with Korean autism spectrum disorders.

Yoo Hee Jeong HJ Cho In Hee IH Park Mira M Yang So Young SY Kim Soon Ae SA

Journal of Korean medical science 20130828 9

This study evaluated the family-based genetic association between autism spectrum disorders (ASDs) and 5 single-nucleotide polymorphisms (SNPs) in the catechol-o-methyltransferase gene (COMT), which was found among 151 Korean ASDs family trios (dominant model Z = 2.598, P = 0.009, P FDR = 0.045). We found a statistically significant allele transmission or association in terms of the rs6269 SNP in the ASDs trios. Moreover, in the haplotype analysis, the haplotypes with rs6269 demonstrated signifi ...[more]

PMID: 24015051

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