Ontology highlight
ABSTRACT:
SUBMITTER: Peters JP
PROVIDER: S-EPMC4190681 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Peters Justin P JP Becker Nicole A NA Rueter Emily M EM Bajzer Zeljko Z Kahn Jason D JD Maher L James LJ
Methods in enzymology 20110101
The double-helical DNA biopolymer is particularly resistant to bending and twisting deformations. This property has important implications for DNA folding in vitro and for the packaging and function of DNA in living cells. Among the outstanding questions in the field of DNA biophysics are the underlying origin of DNA stiffness and the mechanisms by which DNA stiffness is overcome within cells. Exploring these questions requires experimental methods to quantitatively measure DNA bending and twist ...[more]