DNA curvature and flexibility in vitro and in vivo.
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ABSTRACT:
SUBMITTER: Peters JP
PROVIDER: S-EPMC4190679 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
DNA curvature and flexibility in vitro and in vivo.
Peters Justin P JP Maher L James LJ
Quarterly reviews of biophysics 20100201 1
It has been more than 50 years since the elucidation of the structure of double-helical DNA. Despite active research and progress in DNA biology and biochemistry, much remains to be learned in the field of DNA biophysics. Predicting the sequence-dependent curvature and flexibility of DNA is difficult. Applicability of the conventional worm-like chain polymer model of DNA has been challenged. The fundamental forces responsible for the remarkable resistance of DNA to bending and twisting remain co ...[more]
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