Ontology highlight
ABSTRACT:
SUBMITTER: Ritchey L
PROVIDER: S-EPMC4190833 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Ritchey Lisa L Chakrabarti Ratna R
Biochimica et biophysica acta 20140801 11
Aurora A kinase regulates early mitotic events through phosphorylation and activation of a variety of proteins. Specifically, Aur-A is involved in centrosomal separation and formation of mitotic spindles in early prophase. The effect of Aur-A on mitotic spindles is mediated by the modulation of microtubule dynamics and association with microtubule binding proteins. In this study we show that Aur-A exerts its effects on spindle organization through the regulation of the actin cytoskeleton. Aurora ...[more]