Ontology highlight
ABSTRACT:
SUBMITTER: Mandati V
PROVIDER: S-EPMC6721933 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Mandati Vinay V Del Maestro Laurence L Dingli Florent F Lombard Bérangère B Loew Damarys D Molinie Nicolas N Romero Stephane S Bouvard Daniel D Louvard Daniel D Gautreau Alexis M AM Pasmant Eric E Lallemand Dominique D
The Journal of biological chemistry 20190711 35
Although Merlin's function as a tumor suppressor and regulator of mitogenic signaling networks such as the Ras/rac, Akt, and Hippo pathways is well-documented, in mammals as well as in insects, its role during cell cycle progression remains unclear. In this study, using a combination of approaches, including FACS analysis, time-lapse imaging, immunofluorescence microscopy, and co-immunoprecipitation, we show that Ser-518 of Merlin is a substrate of the Aurora protein kinase A during mitosis and ...[more]