Ontology highlight
ABSTRACT:
SUBMITTER: Brito V
PROVIDER: S-EPMC4191006 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Brito Verónica V Giralt Albert A Enriquez-Barreto Lilian L Puigdellívol Mar M Suelves Nuria N Zamora-Moratalla Alfonsa A Ballesteros Jesús J JJ Martín Eduardo D ED Dominguez-Iturza Nuria N Morales Miguel M Alberch Jordi J Ginés Sílvia S
The Journal of clinical investigation 20140902 10
Learning and memory deficits are early clinical manifestations of Huntington's disease (HD). These cognitive impairments have been mainly associated with frontostriatal HD pathology; however, compelling evidence provided by several HD murine models suggests that the hippocampus may contribute to synaptic deficits and memory dysfunction in HD. The neurotrophin receptor p75(NTR) negatively regulates spine density, which is associated with learning and memory; therefore, we explored whether disturb ...[more]