Ontology highlight
ABSTRACT:
SUBMITTER: Shen J
PROVIDER: S-EPMC4191011 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Shen Jikui J Frye Maike M Lee Bonnie L BL Reinardy Jessica L JL McClung Joseph M JM Ding Kun K Kojima Masashi M Xia Huiming H Seidel Christopher C Lima e Silva Raquel R Dong Aling A Hackett Sean F SF Wang Jiangxia J Howard Brian W BW Vestweber Dietmar D Kontos Christopher D CD Peters Kevin G KG Campochiaro Peter A PA
The Journal of clinical investigation 20140902 10
Retinal and choroidal neovascularization (NV) and vascular leakage contribute to visual impairment in several common ocular diseases. The angiopoietin/TIE2 (ANG/TIE2) pathway maintains vascular integrity, and negative regulators of this pathway are potential therapeutic targets for these diseases. Here, we demonstrated that vascular endothelial-protein tyrosine phosphatase (VE-PTP), which negatively regulates TIE2 activation, is upregulated in hypoxic vascular endothelial cells, particularly in ...[more]