Unknown

Dataset Information

0

Tie2 Activation via VE-PTP Inhibition With Razuprotafib as an Adjunct to Latanoprost in Patients With Open Angle Glaucoma or Ocular Hypertension.


ABSTRACT:

Purpose

To evaluate the ocular hypotensive efficacy and safety of razuprotafib, a novel Tie2 activator, when used as an adjunct to latanoprost in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT).

Methods

Subjects with OAG or OHT and an unmedicated IOP from ≥22 mm Hg to <36 mm Hg were randomized to one of three treatment arms: razuprotafib every day (QD) + latanoprost; razuprotafib twice daily (BID) + latanoprost; or latanoprost monotherapy. The primary endpoint was change in mean diurnal IOP from baseline at day 28.

Results

A total of 194 subjects were randomized, and 193 (99.5%) completed the study. Razuprotafib BID + latanoprost resulted in a significantly larger reduction in diurnal IOP than latanoprost alone (7.95 ± 0.26 mmHg vs. 7.04 ± 0.26 mm Hg, P < 0.05). A smaller improvement was observed after 14 days of treatment (7.62 ± 0.26 mm Hg vs. 7.03 ± 0.26 mm Hg, P = 0.11). Razuprotafib QD dosing did not demonstrate additional IOP lowering compared to latanoprost alone. Conjunctival hyperemia on Day 28 increased by 1.1 units on the four-point Efron scale two hours post dose from a baseline value of 0.6 units, and decreased thereafter.

Conclusions

Topical ocular razuprotafib as an adjunct to latanoprost therapy was well tolerated and significantly reduced IOP in patients with OAG/OHT.

Translational relevance

These data support the IOP lowering efficacy of targeting Tie2 activation in Schlemm's canal in the relevant patient population.

SUBMITTER: Brigell M 

PROVIDER: S-EPMC8742526 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4191011 | biostudies-literature
| S-EPMC9309311 | biostudies-literature
| S-EPMC9361429 | biostudies-literature
| S-EPMC1857560 | biostudies-literature
| S-EPMC7859663 | biostudies-literature
| S-EPMC2841111 | biostudies-literature
| S-EPMC9185806 | biostudies-literature
| S-EPMC4453588 | biostudies-literature
| S-EPMC3175210 | biostudies-literature
| S-EPMC7140751 | biostudies-literature