Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC4191031 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Wang Hui H Sun Tao T Hu Jing J Zhang Rui R Rao Yanhua Y Wang Shuai S Chen Rui R McLendon Roger E RE Friedman Allan H AH Keir Stephen T ST Bigner Darell D DD Li Qi-Jing QJ Wang Huibo H Wang Xiao-Fan XF
The Journal of clinical investigation 20140909 10
Glioblastoma (GBM) is the most common and lethal brain tumor in adults. Glioma-initiating cells (GICs) are stem-like cells that have been implicated in glioblastoma progression and recurrence; however, the distinct properties of GICs and non-GICs within GBM tumors are largely uncharacterized. Here, we evaluated stem cell-associated microRNA (miR) expression in GICs from GBM patients and GICs derived from xenografted human glioma cell lines and determined that miR-33a promotes GIC growth and self ...[more]