Ontology highlight
ABSTRACT:
SUBMITTER: Tao Z
PROVIDER: S-EPMC6194143 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Tao Zhennan Z Li Tao T Ma Haiwen H Yang Yihan Y Zhang Chen C Hai Long L Liu Peidong P Yuan Feng F Li Jiabo J Yi Li L Tong Luqing L Wang Yingshuai Y Xie Yang Y Ming Haolang H Yu Shengping S Yang Xuejun X
Cell death & disease 20181018 11
Autophagy is a vital process that involves degradation of long-lived proteins and dysfunctional organelles and contributes to cellular metabolism. Glioma-initiating cells (GICs) have the ability to self-renew, differentiate into heterogeneous types of tumor cells, and sustain tumorigenicity; thus, GICs lead to tumor recurrence. Accumulating evidence indicates that autophagy can induce stem cell differentiation and increase the lethality of temozolomide against GICs. However, the mechanism underl ...[more]