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Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.

ABSTRACT: We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

SUBMITTER: Wolpin BM 

PROVIDER: S-EPMC4191666 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.

Wolpin Brian M BM   Rizzato Cosmeri C   Kraft Peter P   Kooperberg Charles C   Petersen Gloria M GM   Wang Zhaoming Z   Arslan Alan A AA   Beane-Freeman Laura L   Bracci Paige M PM   Buring Julie J   Canzian Federico F   Duell Eric J EJ   Gallinger Steven S   Giles Graham G GG   Goodman Gary E GE   Goodman Phyllis J PJ   Jacobs Eric J EJ   Kamineni Aruna A   Klein Alison P AP   Kolonel Laurence N LN   Kulke Matthew H MH   Li Donghui D   Malats Núria N   Olson Sara H SH   Risch Harvey A HA   Sesso Howard D HD   Visvanathan Kala K   White Emily E   Zheng Wei W   Abnet Christian C CC   Albanes Demetrius D   Andreotti Gabriella G   Austin Melissa A MA   Barfield Richard R   Basso Daniela D   Berndt Sonja I SI   Boutron-Ruault Marie-Christine MC   Brotzman Michelle M   Büchler Markus W MW   Bueno-de-Mesquita H Bas HB   Bugert Peter P   Burdette Laurie L   Campa Daniele D   Caporaso Neil E NE   Capurso Gabriele G   Chung Charles C   Cotterchio Michelle M   Costello Eithne E   Elena Joanne J   Funel Niccola N   Gaziano J Michael JM   Giese Nathalia A NA   Giovannucci Edward L EL   Goggins Michael M   Gorman Megan J MJ   Gross Myron M   Haiman Christopher A CA   Hassan Manal M   Helzlsouer Kathy J KJ   Henderson Brian E BE   Holly Elizabeth A EA   Hu Nan N   Hunter David J DJ   Innocenti Federico F   Jenab Mazda M   Kaaks Rudolf R   Key Timothy J TJ   Khaw Kay-Tee KT   Klein Eric A EA   Kogevinas Manolis M   Krogh Vittorio V   Kupcinskas Juozas J   Kurtz Robert C RC   LaCroix Andrea A   Landi Maria T MT   Landi Stefano S   Le Marchand Loic L   Mambrini Andrea A   Mannisto Satu S   Milne Roger L RL   Nakamura Yusuke Y   Oberg Ann L AL   Owzar Kouros K   Patel Alpa V AV   Peeters Petra H M PH   Peters Ulrike U   Pezzilli Raffaele R   Piepoli Ada A   Porta Miquel M   Real Francisco X FX   Riboli Elio E   Rothman Nathaniel N   Scarpa Aldo A   Shu Xiao-Ou XO   Silverman Debra T DT   Soucek Pavel P   Sund Malin M   Talar-Wojnarowska Renata R   Taylor Philip R PR   Theodoropoulos George E GE   Thornquist Mark M   Tjønneland Anne A   Tobias Geoffrey S GS   Trichopoulos Dimitrios D   Vodicka Pavel P   Wactawski-Wende Jean J   Wentzensen Nicolas N   Wu Chen C   Yu Herbert H   Yu Kai K   Zeleniuch-Jacquotte Anne A   Hoover Robert R   Hartge Patricia P   Fuchs Charles C   Chanock Stephen J SJ   Stolzenberg-Solomon Rachael S RS   Amundadottir Laufey T LT  

Nature genetics 20140803 9

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs169868  ...[more]

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