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A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.


ABSTRACT: We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.

SUBMITTER: Petersen GM 

PROVIDER: S-EPMC2853179 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.

Petersen Gloria M GM   Amundadottir Laufey L   Fuchs Charles S CS   Kraft Peter P   Stolzenberg-Solomon Rachael Z RZ   Jacobs Kevin B KB   Arslan Alan A AA   Bueno-de-Mesquita H Bas HB   Gallinger Steven S   Gross Myron M   Helzlsouer Kathy K   Holly Elizabeth A EA   Jacobs Eric J EJ   Klein Alison P AP   LaCroix Andrea A   Li Donghui D   Mandelson Margaret T MT   Olson Sara H SH   Risch Harvey A HA   Zheng Wei W   Albanes Demetrius D   Bamlet William R WR   Berg Christine D CD   Boutron-Ruault Marie-Christine MC   Buring Julie E JE   Bracci Paige M PM   Canzian Federico F   Clipp Sandra S   Cotterchio Michelle M   de Andrade Mariza M   Duell Eric J EJ   Gaziano J Michael JM   Giovannucci Edward L EL   Goggins Michael M   Hallmans Göran G   Hankinson Susan E SE   Hassan Manal M   Howard Barbara B   Hunter David J DJ   Hutchinson Amy A   Jenab Mazda M   Kaaks Rudolf R   Kooperberg Charles C   Krogh Vittorio V   Kurtz Robert C RC   Lynch Shannon M SM   McWilliams Robert R RR   Mendelsohn Julie B JB   Michaud Dominique S DS   Parikh Hemang H   Patel Alpa V AV   Peeters Petra H M PH   Rajkovic Aleksandar A   Riboli Elio E   Rodriguez Laudina L   Seminara Daniela D   Shu Xiao-Ou XO   Thomas Gilles G   Tjønneland Anne A   Tobias Geoffrey S GS   Trichopoulos Dimitrios D   Van Den Eeden Stephen K SK   Virtamo Jarmo J   Wactawski-Wende Jean J   Wang Zhaoming Z   Wolpin Brian M BM   Yu Herbert H   Yu Kai K   Zeleniuch-Jacquotte Anne A   Fraumeni Joseph F JF   Hoover Robert N RN   Hartge Patricia P   Chanock Stephen J SJ  

Nature genetics 20100124 3


We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-1  ...[more]

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