Ontology highlight
ABSTRACT:
SUBMITTER: Petersen GM
PROVIDER: S-EPMC2853179 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Petersen Gloria M GM Amundadottir Laufey L Fuchs Charles S CS Kraft Peter P Stolzenberg-Solomon Rachael Z RZ Jacobs Kevin B KB Arslan Alan A AA Bueno-de-Mesquita H Bas HB Gallinger Steven S Gross Myron M Helzlsouer Kathy K Holly Elizabeth A EA Jacobs Eric J EJ Klein Alison P AP LaCroix Andrea A Li Donghui D Mandelson Margaret T MT Olson Sara H SH Risch Harvey A HA Zheng Wei W Albanes Demetrius D Bamlet William R WR Berg Christine D CD Boutron-Ruault Marie-Christine MC Buring Julie E JE Bracci Paige M PM Canzian Federico F Clipp Sandra S Cotterchio Michelle M de Andrade Mariza M Duell Eric J EJ Gaziano J Michael JM Giovannucci Edward L EL Goggins Michael M Hallmans Göran G Hankinson Susan E SE Hassan Manal M Howard Barbara B Hunter David J DJ Hutchinson Amy A Jenab Mazda M Kaaks Rudolf R Kooperberg Charles C Krogh Vittorio V Kurtz Robert C RC Lynch Shannon M SM McWilliams Robert R RR Mendelsohn Julie B JB Michaud Dominique S DS Parikh Hemang H Patel Alpa V AV Peeters Petra H M PH Rajkovic Aleksandar A Riboli Elio E Rodriguez Laudina L Seminara Daniela D Shu Xiao-Ou XO Thomas Gilles G Tjønneland Anne A Tobias Geoffrey S GS Trichopoulos Dimitrios D Van Den Eeden Stephen K SK Virtamo Jarmo J Wactawski-Wende Jean J Wang Zhaoming Z Wolpin Brian M BM Yu Herbert H Yu Kai K Zeleniuch-Jacquotte Anne A Fraumeni Joseph F JF Hoover Robert N RN Hartge Patricia P Chanock Stephen J SJ
Nature genetics 20100124 3
We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-1 ...[more]