Ontology highlight
ABSTRACT:
SUBMITTER: Lessel D
PROVIDER: S-EPMC4191733 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Lessel D D Oshima J J Kubisch C C
Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V 20121201 4
Werner syndrome is a segmental progeroid disorder with onset in adolescence or early adulthood. Typical symptoms contributing to patients' prematurely aged appearance include postpubertal development of short stature, cataracts, premature greying/thinning of scalp hair, scleroderma-like skin changes and regional atrophy of subcutaneous fat tissue. In addition, an increased rate and early onset of typical age-related diseases such as type 2 diabetes mellitus, osteoporosis, atherosclerosis, and va ...[more]