Genome-wide DNA methylation profiling of Progeria and Werner syndrome patients
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ABSTRACT: DNA methylation gradiently changes with age and is likely to be involved in aging-related processes resulting in phenotype changes and increased susceptibility to certain diseases. The Hutchinson-Gilford Progeria Syndrome (HGP) and Werner Syndrome are two premature aging diseases showing features of common aging. Mutations in LMNA and WRN genes were associated to disease onset; however for a subset of patients the underlying causative mechanisms remain elusive. We aimed to evaluate the role of epigenetic alteration on premature aging diseases by performing genome-wide DNA methylation profiling of HGP and WS patients.
ORGANISM(S): Homo sapiens
PROVIDER: GSE42865 | GEO | 2013/01/14
SECONDARY ACCESSION(S): PRJNA183678
REPOSITORIES: GEO
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