Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC4192550 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Li Wei W Gong Xiaoyuan X Sun Mingyuan M Zhao Xingli X Gong Benfa B Wei Hui H Mi Yingchang Y Wang Jianxiang J
PloS one 20141009 10
The optimal dose, scheme, and clinical setting for Ara-C in acute myeloid leukemia (AML) treatment remain uncertain. In this study, we performed a meta-analysis to systematically assess the impact of high-dose cytarabine (HDAC) on AML therapy during the induction and consolidation stages. Twenty-two trials with a total of 5,945 de novo AML patients were included in the meta-analysis. Only patients less than 60 year-old were included in the study. Using HDAC in induction therapy was beneficial fo ...[more]