Ontology highlight
ABSTRACT:
SUBMITTER: Frazier-Wood AC
PROVIDER: S-EPMC4192626 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Frazier-Wood Alexis C AC Wojczynski Mary K MK Borecki Ingrid B IB Hopkins Paul N PN Lai Chao-Qiang CQ Ordovas Jose M JM Straka Robert J RJ Tsai Micheal Y MY Tiwari Hemant K HK Arnett Donna K DK
Biology 20140825 3
Lipoprotein subclass concentrations are modifiable markers of cardiovascular disease risk. Fenofibrate is known to show beneficial effects on lipoprotein subclasses, but little is known about the role of genetics in mediating the responses of lipoprotein subclasses to fenofibrate. A recent genomewide association study (GWAS) associated several single nucleotide polymorphisms (SNPs) with lipoprotein measures, and validated these associations in two independent populations. We used this informatio ...[more]