Cervical spinal cord injury: tailoring clinical trial endpoints to reflect meaningful functional improvements.
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ABSTRACT:
SUBMITTER: Bond LM
PROVIDER: S-EPMC4192962 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
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Cervical spinal cord injury: tailoring clinical trial endpoints to reflect meaningful functional improvements.
Bond Lisa M LM McKerracher Lisa L
Neural regeneration research 20140801 16
Cervical spinal cord injury (SCI) results in partial to full paralysis of the upper and lower extremities. Traditional primary endpoints for acute SCI clinical trials are too broad to assess functional recovery in cervical subjects, raising the possibility of false positive outcomes in trials for cervical SCI. Endpoints focused on the recovery of hand and arm control (e.g., upper extremity motor score, motor level change) show the most potential for use as primary outcomes in upcoming trials of ...[more]
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