Independent hypothalamic circuits for social and predator fear.
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ABSTRACT:
SUBMITTER: Silva BA
PROVIDER: S-EPMC4194278 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Independent hypothalamic circuits for social and predator fear.
Silva Bianca A BA Mattucci Camilla C Krzywkowski Piotr P Murana Emanuele E Illarionova Anna A Grinevich Valery V Canteras Newton S NS Ragozzino Davide D Gross Cornelius T CT
Nature neuroscience 20131110 12
The neural circuits mediating fear to naturalistic threats are poorly understood. We found that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region that has been implicated in feeding, sex and aggression, are essential for predator and social fear in mice. Our results establish a critical role for VMH in fear and have implications for selective intervention in pathological fear in humans. ...[more]
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