Ontology highlight
ABSTRACT:
SUBMITTER: Okamoto K
PROVIDER: S-EPMC419534 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Okamoto Ken K Matsumoto Koji K Hille Russ R Eger Bryan T BT Pai Emil F EF Nishino Takeshi T
Proceedings of the National Academy of Sciences of the United States of America 20040517 21
Molybdenum is widely distributed in biology and is usually found as a mononuclear metal center in the active sites of many enzymes catalyzing oxygen atom transfer. The molybdenum hydroxylases are distinct from other biological systems catalyzing hydroxylation reactions in that the oxygen atom incorporated into the product is derived from water rather than molecular oxygen. Here, we present the crystal structure of the key intermediate in the hydroxylation reaction of xanthine oxidoreductase with ...[more]