Ontology highlight
ABSTRACT:
SUBMITTER: Kipnis J
PROVIDER: S-EPMC419577 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Kipnis Jonathan J Cohen Hagit H Cardon Michal M Ziv Yaniv Y Schwartz Michal M
Proceedings of the National Academy of Sciences of the United States of America 20040512 21
The effects of the adaptive immune system on the cognitive performance and abnormal behaviors seen in mental disorders such as schizophrenia have never been documented. Here, we show that mice deprived of mature T cells manifested cognitive deficits and behavioral abnormalities, which were remediable by T cell restoration. T cell-based vaccination, using glatiramer acetate (copolymer-1, a weak agonist of numerous self-reactive T cells), can overcome the behavioral and cognitive abnormalities tha ...[more]