Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis.
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ABSTRACT:
SUBMITTER: Ortiz B
PROVIDER: S-EPMC4196177 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis.
Ortiz Berenice B White Julie R JR Wu Wei H WH Chan Timothy A TA
Oncotarget 20140801 16
PTPRD encodes the protein tyrosine phosphatase receptor type D and is frequently inactivated across many human cancers. Despite its frequent inactivation, it is unknown whether loss of PTPRD promotes tumorigenesis in vivo. PTPRD is located on chromosome 9p, as is CDKN2A, and the two loci are frequently deleted together. Here, we show that co-deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis. Interestingly,heterozygous loss of Ptprd was sufficient to promote tumorigenesis in our ...[more]
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