Ontology highlight
ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC6264643 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Zhang Peng P He Fuhong F Bai Jie J Yamamoto Shohei S Chen Shi S Zhang Lin L Sheng Mengyao M Zhang Lei L Guo Ying Y Man Na N Yang Hui H Wang Suyun S Cheng Tao T Nimer Stephen D SD Zhou Yuan Y Xu Mingjiang M Wang Qian-Fei QF Yang Feng-Chun FC
The Journal of clinical investigation 20181029 12
ASXL1 is frequently mutated in myeloid malignancies and is known to co-occur with other gene mutations. However, the molecular mechanisms underlying the leukemogenesis associated with ASXL1 and cooperating mutations remain to be elucidated. Here, we report that Asxl1 loss cooperated with haploinsufficiency of Nf1, a negative regulator of the RAS signaling pathway, to accelerate the development of myeloid leukemia in mice. Loss of Asxl1 and Nf1 in hematopoietic stem and progenitor cells resulted ...[more]