Ontology highlight
ABSTRACT:
SUBMITTER: Ritchie TK
PROVIDER: S-EPMC4196316 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Ritchie T K TK Grinkova Y V YV Bayburt T H TH Denisov I G IG Zolnerciks J K JK Atkins W M WM Sligar S G SG
Methods in enzymology 20090101
Self-assembled phospholipid bilayer Nanodiscs have become an important and versatile tool among model membrane systems to functionally reconstitute membrane proteins. Nanodiscs consist of lipid domains encased within an engineered derivative of apolipoprotein A-1 scaffold proteins, which can be tailored to yield homogeneous preparations of disks with different diameters, and with epitope tags for exploitation in various purification strategies. A critical aspect of the self-assembly of target me ...[more]