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The SOS Regulatory Network.

ABSTRACT: All organisms possess a diverse set of genetic programs that are used to alter cellular physiology in response to environmental cues. The gram-negative bacterium, Escherichia coli, mounts what is known as the "SOS response" following DNA damage, replication fork arrest, and a myriad of other environmental stresses. For over 50 years, E. coli has served as the paradigm for our understanding of the transcriptional, and physiological changes that occur following DNA damage (400). In this chapter, we summarize the current view of the SOS response and discuss how this genetic circuit is regulated. In addition to examining the E. coli SOS response, we also include a discussion of the SOS regulatory networks in other bacteria to provide a broader perspective on how prokaryotes respond to DNA damage.

SUBMITTER: Simmons LA

PROVIDER: S-EPMC4196698 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

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The SOS Regulatory Network.

Simmons Lyle A LA Foti James J JJ Cohen Susan E SE Walker Graham C GC

EcoSal Plus 20080701

All organisms possess a diverse set of genetic programs that are used to alter cellular physiology in response to environmental cues. The gram-negative bacterium, Escherichia coli, mounts what is known as the "SOS response" following DNA damage, replication fork arrest, and a myriad of other environmental stresses. For over 50 years, E. coli has served as the paradigm for our understanding of the transcriptional, and physiological changes that occur following DNA damage (400 ...[more]

PMID: 25325076

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Integrated transcriptional regulatory network of quorum sensing, replication, and SOS response in Dinoroseobacter shibae

Project description:Integrated transcriptional regulatory network of quorum sensing, replication, and SOS response in Dinoroseobacter shibae

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