Ontology highlight
ABSTRACT:
SUBMITTER: Cheng JB
PROVIDER: S-EPMC419671 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Cheng Jeffrey B JB Levine Michael A MA Bell Norman H NH Mangelsdorf David J DJ Russell David W DW
Proceedings of the National Academy of Sciences of the United States of America 20040505 20
The synthesis of bioactive vitamin D requires hydroxylation at the 1 alpha and 25 positions by cytochrome P450 enzymes in the kidney and liver, respectively. The mitochondrial enzyme CYP27B1 catalyzes 1 alpha-hydroxylation in the kidney but the identity of the hepatic 25-hydroxylase has remained unclear for >30 years. We previously identified the microsomal CYP2R1 protein as a potential candidate for the liver vitamin D 25-hydroxylase based on the enzyme's biochemical properties, conservation, a ...[more]