Ontology highlight
ABSTRACT:
SUBMITTER: Yan W
PROVIDER: S-EPMC419685 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Yan Wei W Ma Lang L Burns Kathleen H KH Matzuk Martin M MM
Proceedings of the National Academy of Sciences of the United States of America 20040510 20
We identified a testis-specific gene encoding a protein containing a BTB/POZ domain and six kelch repeats, which we named kelch homolog 10 (KLHL10). KLHL10 displays high evolutionary conservation in mammals, as evidenced by 98.7% amino acid identity between mouse and human KLHL10. KLHL10 is exclusively expressed in the cytoplasm of elongating and elongated spermatids (steps 9-16). We generated a Klhl10 null allele in 129S6/SvEv mouse embryonic stem cells, and obtained 47 chimeras from six indepe ...[more]