Ontology highlight
ABSTRACT:
SUBMITTER: Lee E
PROVIDER: S-EPMC4197055 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20130221 5
<h4>Background</h4>Female steroid hormone levels and exogenous hormone use influence breast cancer risk. We investigated the association between genetic variation in the hormone metabolism and signaling pathway and mammographic density, a strong predictor of breast cancer risk.<h4>Methods</h4>We genotyped 161 SNPs in 15 hormone metabolism pathway gene regions and evaluated mammographic density in 2,038 Singapore Chinese women. Linear regression analysis was used to investigate single-nucleotide ...[more]