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Estrogen metabolism and mammographic density in postmenopausal women: a cross-sectional study.

ABSTRACT: BACKGROUND:Prospective studies have consistently found that postmenopausal breast cancer risk increases with circulating estrogens; however, findings from studies of estrogens and mammographic density (MD), an intermediate marker of breast cancer risk, have been inconsistent. We investigated the cross-sectional associations of urinary estrogens, and their 2-, 4-, and 16-hydroxylated metabolites with MD. METHODS:Postmenopausal women without breast cancer (n = 194), ages 48 to 82 years, and reporting no current menopausal hormone therapy use were enrolled at a clinic in Western NY in 2005. Urinary estrogens and estrogen metabolites were measured using mass spectrometry. Percent MD and dense area (cm(2)) were measured using computer-assisted analyses of digitized films. Linear regression models were used to estimate associations of log-transformed estrogen measures with MD while adjusting for age, body mass index (BMI), parity, and past hormone therapy use. RESULTS:Urinary concentrations of most individual estrogens and metabolites were not associated with MD; however, across the interdecile range of the ratio of parent estrogens (estrone and estradiol) to their metabolites, MD increased by 6.8 percentage points (P = 0.02) and dense area increased by 10.3 cm(2) (P = 0.03). Across the interdecile ranges of the ratios of 2-, 4-, and 16-hydroxylation pathways to the parent estrogens, MD declined by 6.2 (P = 0.03), 6.4 (P = 0.04), and 5.7 (P = 0.05) percentage points, respectively. All associations remained apparent in models without adjustment for BMI. CONCLUSION:In this study of postmenopausal women, less extensive hydroxylation of parent estrogens was associated with higher MD. IMPACT:Hydroxylation of estrogens may modulate postmenopausal breast cancer risk through a pathway involving MD.

SUBMITTER: Fuhrman BJ

PROVIDER: S-EPMC3436977 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Estrogen metabolism and mammographic density in postmenopausal women: a cross-sectional study.

Fuhrman Barbara J BJ Brinton Louise A LA Pfeiffer Ruth M RM Xu Xia X Veenstra Timothy D TD Teter Barbara E BE Byrne Celia C Dallal Cher M CM Barba Maddalena M Muti Paola C PC Gierach Gretchen L GL

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20120626 9

<h4>Background</h4>Prospective studies have consistently found that postmenopausal breast cancer risk increases with circulating estrogens; however, findings from studies of estrogens and mammographic density (MD), an intermediate marker of breast cancer risk, have been inconsistent. We investigated the cross-sectional associations of urinary estrogens, and their 2-, 4-, and 16-hydroxylated metabolites with MD.<h4>Methods</h4>Postmenopausal women without breast cancer (n = 194), ages 48 to 82 ye ...[more]

PMID: 22736791

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Dataset Information

Estrogen metabolism and mammographic density in postmenopausal women: a cross-sectional study.

Publications

Estrogen metabolism and mammographic density in postmenopausal women: a cross-sectional study.

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