Ontology highlight
ABSTRACT:
SUBMITTER: Shi Y
PROVIDER: S-EPMC4197414 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Shi Yang Y Zhou Hao H Zhang Xiaoli X Wang Jingyu J Long Jiafu J Yang Zhimou Z Ding Dan D
Scientific reports 20141015
Streptococcus pneumoniae (pneumococcus) causes multiple illnesses in humans. Exploration of effective inhibitors with multivalent attachment sites for choline-binding modules is of great importance to reduce the pneumococcal virulence. In this work, we successfully developed two self-assembling choline mimicks, Ada-GFFYKKK' and Nap-GFFYKKK', which have the abilities to self-assemble into nanoparticles and nanofibers, respectively, yielding multivalent architectures. Additionally, the best charac ...[more]