Ontology highlight
ABSTRACT:
SUBMITTER: Swartz SZ
PROVIDER: S-EPMC4197533 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Swartz S Zachary SZ Reich Adrian M AM Oulhen Nathalie N Raz Tal T Milos Patrice M PM Campanale Joseph P JP Hamdoun Amro A Wessel Gary M GM
Development (Cambridge, England) 20140801 16
A crucial event in animal development is the specification of primordial germ cells (PGCs), which become the stem cells that create sperm and eggs. How PGCs are created provides a valuable paradigm for understanding stem cells in general. We find that the PGCs of the sea urchin Strongylocentrotus purpuratus exhibit broad transcriptional repression, yet enrichment for a set of inherited mRNAs. Enrichment of several germline determinants in the PGCs requires the RNA-binding protein Nanos to target ...[more]