Ontology highlight
ABSTRACT:
SUBMITTER: Oka Y
PROVIDER: S-EPMC4198039 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Oka Yasuyoshi Y Varmark Hanne H Vitting-Seerup Kristoffer K Beli Petra P Waage Johannes J Hakobyan Anna A Mistrik Martin M Choudhary Chunaram C Rohde Mikkel M Bekker-Jensen Simon S Mailand Niels N
EMBO reports 20140804 9
UBL5 is an atypical ubiquitin-like protein, whose function in metazoans remains largely unexplored. We show that UBL5 is required for sister chromatid cohesion maintenance in human cells. UBL5 primarily associates with spliceosomal proteins, and UBL5 depletion decreases pre-mRNA splicing efficiency, leading to globally enhanced intron retention. Defective sister chromatid cohesion is a general consequence of dysfunctional pre-mRNA splicing, resulting from the selective downregulation of the cohe ...[more]