Ontology highlight
ABSTRACT:
SUBMITTER: Bickel SE
PROVIDER: S-EPMC450050 | biostudies-other | 1996 Mar
REPOSITORIES: biostudies-other
Bickel S E SE Wyman D W DW Miyazaki W Y WY Moore D P DP Orr-Weaver T L TL
The EMBO journal 19960301 6
Attachment between the sister chromatids is required for proper chromosome segregation in meiosis and mitosis, but its molecular basis is not understood. Mutations in the Drosophila ord gene result in premature sister chromatid separation in meiosis, indicating that the product of this gene is necessary for sister chromatid cohesion. We isolated the ord gene and found that it encodes a novel 55 kDa protein. Some of the ord mutations exhibit unusual complementation properties, termed negative com ...[more]