Ontology highlight
ABSTRACT:
SUBMITTER: Askarian F
PROVIDER: S-EPMC4198549 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Askarian Fatemeh F van Sorge Nina M NM Sangvik Maria M Beasley Federico C FC Henriksen Jørn R JR Sollid Johanna U E JU van Strijp Jos A G JA Nizet Victor V Johannessen Mona M
Journal of innate immunity 20140125 4
Signaling through Toll-like receptors (TLRs), crucial molecules in the induction of host defense responses, requires adaptor proteins that contain a Toll/interleukin-1 receptor (TIR) domain. The pathogen Staphylococcus aureus produces several innate immune-evasion molecules that interfere with the host's innate immune response. A database search analysis suggested the presence of a gene encoding a homologue of the human TIR domain in S. aureus MSSA476 which was named staphylococcal TIR domain pr ...[more]