Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC4199126 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Zhang Xiaohong X Martinez Denisse D Koledova Zuzana Z Qiao Guijuan G Streuli Charles H CH Lu Pengfei P
Development (Cambridge, England) 20140730 17
FGF signaling is essential for mammary gland development, yet the mechanisms by which different members of the FGF family control stem cell function and epithelial morphogenesis in this tissue are not well understood. Here, we have examined the requirement of Fgfr2 in mouse mammary gland morphogenesis using a postnatal organ regeneration model. We found that tissue regeneration from basal stem cells is a multistep event, including luminal differentiation and subsequent epithelial branching morph ...[more]