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Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals.

ABSTRACT: Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secreted by fibroblasts and fibroblast-derived modifications of the matrix compliance contribute to the regulation of epithelial cell morphogenesis. Readjustment of matrix tension by fibroblasts can even induce a phenotypic reversion of breast carcinoma cells. These data offer a basis to develop new strategies for the normalization of the tumor stroma as an innovative target in cancer therapy.

SUBMITTER: Luhr I

PROVIDER: S-EPMC3708601 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals.

Lühr Inke I Friedl Andreas A Overath Thorsten T Tholey Andreas A Kunze Thomas T Hilpert Felix F Sebens Susanne S Arnold Norbert N Rösel Frank F Oberg Hans-Heinrich HH Maass Nicolai N Mundhenke Christoph C Jonat Walter W Bauer Maret M

Cancer letters 20120707 2

Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secreted by fibroblasts and fibroblast-derived modifications of the matrix compliance contribute to the regulation of epithelial cell morphogenesis. Readjustment of matrix tension by fibroblasts can even ind ...[more]

PMID: 22776560

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